Atomic Structure of Dual-Specificity Phosphatase 26, a Novel p53 Phosphatase
نویسندگان
چکیده
منابع مشابه
High-resolution crystal structure of the catalytic domain of human dual-specificity phosphatase 26.
Dual-specificity phosphatases (DUSPs) play an important role in regulating cellular signalling pathways governing cell growth, differentiation and apoptosis. Human DUSP26 inhibits the apoptosis of cancer cells by dephosphorylating substrates such as p38 and p53. High-resolution crystal structures of the DUSP26 catalytic domain (DUSP26-C) and its C152S mutant [DUSP26-C (C152S)] have been determi...
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PIR1 is an atypical dual-specificity phosphatase (DSP) that dephosphorylates RNA with a higher specificity than phosphoproteins. Here we report the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 Å resolution. PIR1-core shares structural similarities with DSPs related to Vaccinia virus VH1 and with RNA ...
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References 1 Gething, M. J. and Sambrook, J. (1992) Nature 355, 33-45 2 Lewis, M. J. and Pelham, H. R. B. (1992) Cell 68, 353-364 3 Kaiser, C. A. and Schekman, R. (1990) Cell 61, 723-733 4 Bennett, M. K., Calakos, M. and Scheller, R. H. (1992) Science 257, 255-259 5 Rothman, J. E. and Orci, L. (1992) Nature 355, 409-415 6 Quinn, P., Griffiths, G. and Warren G. (1984) J. Cell BioL 98, 2142-2147 ...
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Dual-specificity protein phosphatases (DSPs) play roles in the regulation of mitogenic signal transduction for extracellular stimulation and the cell cycle. In the present study, we identified a novel DSP, termed TMDP (testis- and skeletal-muscle-specific DSP). Nucleotide sequence analysis of TMDP cDNA indicated that the open reading frame of 597 bp encodes a protein of 198 amino acid residues ...
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ERK MAP kinase plays a key role in relaying extracellular signals to transcriptional regulation. As different activity levels or the different duration of ERK activity can elicit distinct responses in one and the same cell, ERK has to be under strict positive and negative control. Although numerous genes acting positively in the ERK signaling pathway have been recovered in genetic screens, muta...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2013
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi301476m